Thus, the literature and current practices for characterizing tumor KRAS mutation don't accurately reflect the nature of colon tumorKRAS mutation, even though an accurate understanding is critical for identifying the best strategies for intervention.
Linoleic acid intake is associated with colon tumors with an aberrant KRAS gene, but an intact APC gene and MLH1 expression, suggesting a unique etiology of tumors with specific genetic aberrations.
Therefore, K-RAS codon 12 GAT and GTT mutant fractions were measured in colonic mucosa of individuals without colon cancer, tumor-distal mucosa, tumor-proximal mucosa, normal tumor-adjacent tissues, colonic adenomas, and carcinomas.